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Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 2011 Dec; 17(4):251-7. Gastroenterology. 2012 Apr; 56(4):965-72. 1994 Dec; 124(6):755-60. 2002 Jul; 283(1):G204-11. Arch Clin Biomed Res. Carethers will report directly to the chancellor and is part of the leadership team. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Hellerbrand C, Jobin C, Licato LL, Sartor RB. 2013 Dec; 58(6):1930-40. Fibrogenesis of parenchymal organs. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 1998 May; 27(5):1285-95. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. Fra, Fra away: the complex role of activator protein 1 in liver injury. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Biochim Biophys Acta. J Biol Chem. 2014 Aug; 124(8):3566-78. Biochem Biophys Res Commun. 2005; 23(3-4):264-74. Mol Cell Biol. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. J Clin Invest. Aliment Pharmacol Ther. 1993 Feb; 17(2):287-92. Transforming growth factor B and hepatic fibrosis: cause or effect? Cell Metab. 2012 Jun; 56(6):1283-92. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. 1994 Sep; 14 (9):5950-60. 2008 Dec; 48(6):2016-26. 2004 Jan; 2(1):9-13. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Nat Rev Gastroenterol Hepatol. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. J Immunol. 2001 Dec; 35(6):749-55. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. 2003 Jan 10; 278(2):927-33. 1998 Jul; 43(7):1454-64. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 2012 Nov; 67(11):1357-64. 2015 Apr 06; 212(4):469-80. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Hepatic porphyrias. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 2002 Jul; 283(1):C347-57. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. 2006 May; 130(6):1886-900. J Theor Biol. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 2003 Mar; 37(3):493-503. 2011 May; 53(5):1730-41. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 1996 Sep; 50(3):656-61. Quadruple genetic variants in a sporadic ALS patient. Akt activation protects rat liver from ischemia/reperfusion injury. Am J Physiol Gastrointest Liver Physiol. Hepatology. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 2012 Mar; 10(3):285-90.e1. Nat Rev Gastroenterol Hepatol. Am J Clin Nutr. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. 2004 May 28; 279(22):23822-9. J Gastroenterol Hepatol. DNA Cell Biol. J Gastroenterol Hepatol. Alteration of interferon-a/ receptors in chronic hepatitis B patients. 2005 Jun 10; 280(23):21763-72. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. 2009 May; 40(5):1721-8. Hepatology. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Hepatology. J Clin Invest. 2010 Jul; 139(1):323-34.e7. Hepatology. 2015 Feb; 4(1):34-47. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Contribution of bone marrow-derived fibrocytes to liver fibrosis. 2005 Sep-Oct; 7(9-10):1346-55. J Clin Invest. J Clin Immunol. 2005 Mar; 39(3):181-8. J Biol Chem. Proc Am Thorac Soc. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Liver: DNA methylation controls liver fibrogenesis. 2007 May; 132(6):2272-5. Cell Death Differ. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. 1991; 10(3-4):452-5. Hepatology. J Hepatol. Semin Liver Dis. 2000 Nov 01; 28(21):4306-16. 2020 May 05; 56(5). J Hepatol. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Am J Physiol. 2017 Jun 16; 7:314-323. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics 1994 Sep; 17(3):410-2. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. J Hepatol. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. Am J Physiol Heart Circ Physiol. Integr Biol (Camb). Front Physiol. 2000 Dec; 32(6):1272-9. Proc Natl Acad Sci U S A. 2010 Sep; 139(3):836-45, 845.e1. 2012 Jun 12; 109(24):9448-53. 2009 Sep; 1(8-9):513-24. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Hepatology. 2001 Aug 17; 89(4):351-6. 2000 Jun 01; 95(11):3568-77. 2003 Mar 07; 278(10):8083-90. 2012 Nov; 13(11):1072-82. Hepatobiliary Surg Nutr. 1994 Dec 09; 269(49):30789-97. 2009 Nov; 58(11):1517-27. Am J Physiol Gastrointest Liver Physiol. 1987 Dec 25; 262(36):17690-5. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. 2013 Jun; 45(6):450-9. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Hepatology. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Dig Dis Sci. J Hepatol. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2018 12; 16(12):1974-1982.e7. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Gastroenterology. Hepatology. 2001 Sep; 25(9):1360-7. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 2004 Feb; 24(4):1758-68. 2009 Oct; 137(4):1467-1477.e5. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. The enteropathy of prostaglandin deficiency. Am J Pathol. Hepatology. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Am J Physiol Gastrointest Liver Physiol. Hepatology. 2011 Jul; 179(1):189-98. Altman Clinical and Translational Research Institute (ACTRI). Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Therapy for hepatic fibrosis. Expression of human immunodeficiency virus-1 in human colonic cells. 2021 11; 25(11):2149-2159. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Dig Dis. 2021 08; 74(2):667-685. 2001 Jun; 280(6):G1178-86. Gastroenterology. J Exp Med. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Mol Cell Biol. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. 2019 03 29; 10(1):1406. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Cancer Res. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Stem Cells Cloning. 1997 Nov; 113(5):1589-98. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! 2003 Jan 01; 8:d69-77. 2000 Mar; 15 Suppl:D20-5. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. 2010 Sep; 139(3):987-98. 2018 06; 67(6):2150-2166. 1990 Feb; 10(2):689-95. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. To return to the graph. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. 2007 Apr; 132(4):1434-46. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. 1993 Dec; 92(6):2916-21. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. 1999 Oct 22; 274(43):30919-26. 1989 Aug 11; 17(15):6055-64. 2012 Nov; 143(5):1330-1340.e1. 2007 Aug; 47(2):307-9. J Biol Chem. Note that an individual publication can be assigned to more than one field. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 2000 Dec; 279(6):G1333-42. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. 2020; 15(6):e0234038. J Gastroenterol Hepatol. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Gastroenterology. J Clin Invest. Am J Physiol Gastrointest Liver Physiol. Ann Hepatol. Am J Physiol. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. 2006 May; 130(6):1562. Am J Physiol Gastrointest Liver Physiol. Mol Genet Genomic Med. Activation of Jun kinase is an early event in hepatic regeneration. 2016 08; 65(2):369-76. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. JCI Insight. Hepatology. J Immunol. Arch Biochem Biophys. 2000 Apr 21; 275(16):11814-23. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 1998 Aug; 115(2):443-51. 2017 Aug; 40(2):454-464. The role of Smad3 in mediating mouse hepatic stellate cell activation. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Recent advancement of molecular mechanisms of liver fibrosis. 2006 Sep; 131(3):957-60. 1999 03; 276(3):G591-8. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Gastroenterology. 2005 Feb; 115(2):209-18. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. 1989 Feb 16; 337(6208):661-3. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Hepatology. 1998 Oct; 27(3):192-8. 2014 Mar 07; 289(10):7082-7091. 1998 Nov; 18(11):6353-64. 1995 Sep; 9(9):1157-65. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2003 May; 73(1):44-52. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Prog. J Burn Care Rehabil. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Cell Death Differ. 2003 Feb; 124(2):445-58. 2010 Feb 25; 3:39-47. 2006 Oct; 21 Suppl 3:S84-7. 2006 Apr; 290(4):G583-9. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Gastroenterology. 1998 Feb; 2(1):77-102, vi. 2005 Sep 16; 335(1):87-96. Hepatology. 2020; 11:370. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Semin Liver Dis. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Blood. Science. Curr Opin Gastroenterol. 2012 Sep; 56(3):922-32. Gut. Signal transduction during liver regeneration. J Clin Invest. 2021 07 20; 118(29). 2000 Feb; 31(2):391-8. 2018 01; 53(1):6-17. Hepatology. 2016 07; 111(7):986-94. The future of gastroenterology and gastroenterology. 2010 Feb; 16(2):181-90. PLoS One. What is the potential role of antifibrotic agents for the treatment of liver disease? 2010 Oct; 52(4):1390-400. J Hum Nutr Diet. 2014 Jul; 124(7):2921-34. J Hepatol. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. 2013 Mar; 37(6):630-9. 2003 Apr 15; 170(8):4053-60. 2011 Jan; 53(1):96-105. Exercise training attenuates age-associated diastolic dysfunction in rats. Proc Natl Acad Sci U S A. Am J Physiol. Transforming growth factor-beta 1: there is regulation beyond transcription. Gastroenterology. Comparison of human and bovine protoporphyria. Hepatol Commun. 1986 Mar; 83(6):1762-6. PLoS One. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Proc Natl Acad Sci U S A. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 2002 Sep; 132(3):441-9. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Infect Immun. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Clin Gastroenterol Hepatol. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. 2017 02; 152(3):598-607.e2. 2005 Nov; 29(11 Suppl):102S-109S. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 2002 May 17; 277(20):18229-37. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 2009 Jan; 49(1):6-8. Hepatology. 2010 Oct; 52(4):1420-30. Mol Cell Biol. 2016; 34(5):589-96. Gastroenterology. J Clin Invest. 2008 Sep; 5(9):496-7. DNA. Antioxid Redox Signal. Promising Therapy Candidates for Liver Fibrosis. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 1999 Aug; 31(4):305-19. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. 2020 05; 72(5):946-959. J Biol Chem. 2015 Feb; 21(2):159-65. 2009 Mar 03; 106(9):3300-5. Toll-like receptors and adaptor molecules in liver disease: update. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. This graph shows the total number of publications by year. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. 1999 09; 277(3):G671-7. 2020 12; 72(6):2182-2196. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Am J Physiol Cell Physiol. A simplified method for the preparation of transcriptionally active liver nuclear extracts. 2003 Oct; 125(4):1009. 1998 Sep; 13 Suppl:S93-5. 2020 02 13; 5(3). J Gastroenterol Hepatol. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. 2017 Jun 30; 127(7):2697-2704. Nuclear factor-kappaB in the liver: friend or foe? Neurology. J Biol Chem. J Biol Chem. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Mechanisms of fibrogenesis. J Cell Biol. J Clin Invest. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. 1999 Jun; 19(6):4334-42. Gastroenterol Hepatol (N Y). NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Nat Commun. Fibrogenesis and type I collagen gene regulation. 1995 Oct; 6(10):1285-90. Int J Mol Med. medRxiv. 2009 Jan 16; 378(3):348-53. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. 1994 Jul 29; 269(30):19203-6. Cell Metab. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Am J Pathol. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus 1996 Sep; 24(3):670-6. 2001 Jul; 34(1):89-100. J Cardiovasc Med (Hagerstown). Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. 1993 Jan; 264(1 Pt 1):G95-103. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Gastroenterology. Gastroenterology. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. 1987 Sep; 79(3):449-56. Am J Pathol. Hepatol Commun. 2005 Jan; 54(1):134-41. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. J Surg Res. 2013 Mar; 62(3):335-6. Hepatology. 2001 Jan; 280(1):G139-48. 2020; 15(3):e0229445. 2019 Sep 03; 30(3):607. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. 2016 Sep; 92(3):84-92. Am J Respir Cell Mol Biol. Dig Liver Dis. 2007 Mar; 14(3):568-75. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? 2012 Jun; 10(6):575-80. Cloning of murine ferrochelatase. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. The fecal microbiome of ALS patients. J Clin Invest. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Nucleic Acids Res. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. 2017 01; 65(1):78-88. Gut. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Transient induction of c-jun during hepatic regeneration. 1998 Sep; 13 Suppl:S39-50. Surgery. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Nat Commun. Blood. Immunol Res. Best Pract Res Clin Gastroenterol. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Cell Death Differ. Nat Immunol. Hepatology. 1995 Feb; 95(2):803-10. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. 1995 Sep 29; 270(39):22689-92. 2014 Aug 12; 111(32):E3297-305. 2021; 12(3):891-920. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Alzheimer's disease: the vascular connection. Mol Ther Nucleic Acids. Methods Mol Biol. Am J Physiol. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. 2013 Apr; 144(4):661-3. Nature. Exp Biol Med (Maywood). Gastroenterology. 1997 May; 272(5 Pt 1):G943-53. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. We lose people all of the time. Alcohol Clin Exp Res. 1999 Mar; 31(2):173-9. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Gastroenterology. Hepatology. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. 2013 Nov; 9(11):737-9. Hepatology. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. 2019 10; 68(10):1884-1892. Migration of fibrocytes in fibrogenic liver injury. Proc Natl Acad Sci U S A. 2018 01; 30(1):31-38. 2001 Apr; 120(5):1251-62. 2014 May; 146(6):1513-24. 1988 Sep-Oct; 8(5):1040-5. 2006 Jul; 37(7):1691-6. 2001 Jul 10; 104(2):221-6. Blood. 2003 May; 37(5):1043-55. Interactions between the intestinal microbiome and liver diseases. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. 2013 Feb 01; 12(3):381-2. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 1997 Jan 17; 272(3):1753-60. Am J Physiol Gastrointest Liver Physiol. Nat Commun. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Aliment Pharmacol Ther. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. Kenji Fujiwara, MD, PhD. He did not respond to inewsource s interview request. Hepatology. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Mol Cell Biol. 2015 Jan; 22(1):164-73. Human hepatic stellate cell isolation and characterization. Yang L, Magness ST, Bataller R, Rippe RA. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. 2020 12 15; 95(24):e3163-e3179. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Am J Physiol Gastrointest Liver Physiol. J Clin Invest. 2009 Oct; 297(4):G726-34. Researchers can. 1990 Feb; 10(1):75-83. 2003 Sep; 285(3):G642-51. Gastroenterol Res Pract. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. Alcohol Clin Exp Res. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2012; 5(Suppl 1):S17. CCR1 and CCR5 promote hepatic fibrosis in mice. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. J Biol Chem. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. S, Sols-Herruzo JA 2 in primary rat hepatocytes oxidase 1 in liver injury and excessive alcohol drinking in.! 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